| Passing Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Completions | Kurt Warner - Arizona | New York (AFC) | 9/28/2008 | New York (AFC) 31-28 | 58 |
| Most Passing Yards | Kurt Warner - Arizona | New York (AFC) | 9/28/2008 | New York (AFC) 31-28 | 561 |
| Best Avg Yards Per Pass | Chad Pennington - Miami | Oakland | 11/16/2008 | Miami 46-0 | 12.6 |
| Longest Completion | Kurt Warner - Arizona | Seattle | 11/16/2008 | Seattle 32-13 | 94 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Completions | Arizona | New York (AFC) | 9/28/2008 | New York (AFC) 31-28 | 58 |
| Most Passing Yards | Arizona | New York (AFC) | 9/28/2008 | New York (AFC) 31-28 | 561 |
| Best Avg Yards Per Pass | Arizona | St. Louis | 11/2/2008 | Arizona 47-34 | 12.6 |
| Longest Completion | Arizona | Seattle | 11/16/2008 | Seattle 32-13 | 94 |
| Rushing Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Carries | Adrian L. Peterson - Minnesota | Chicago | 11/30/2008 | Chicago 31-23 | 34 |
| Most Rushing Yards | Adrian L. Peterson - Minnesota | Green Bay | 11/9/2008 | Minnesota 42-24 | 282 |
| Best Rushing Avg | DeAngelo Williams - Carolina | Atlanta | 11/23/2008 | Atlanta 55-35 | 11.8 |
| Longest Carry | Jerome Harrison - Cleveland | Pittsburgh | 9/14/2008 | Cleveland 19-13 | 72 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Carries | Indianapolis | Cleveland | 11/30/2008 | Indianapolis 31-19 | 53 |
| Most Rushing Yards | Minnesota | Green Bay | 11/9/2008 | Minnesota 42-24 | 328 |
| Best Rushing Avg | Carolina | Atlanta | 11/23/2008 | Atlanta 55-35 | 9.7 |
| Longest Carry | Cleveland | Pittsburgh | 9/14/2008 | Cleveland 19-13 | 72 |
| Receiving Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Receptions | Edgerrin James - Arizona | New York (AFC) | 9/28/2008 | New York (AFC) 31-28 | 17 |
| Most Receiving Yards | Ted Ginn Jr. - Miami | Buffalo | 12/7/2008 | Miami 31-17 | 217 |
| Best Reception Yardage Avg | Ted Ginn Jr. - Miami | Buffalo | 12/7/2008 | Miami 31-17 | 36.2 |
| Longest Reception | Anquan Boldin - Arizona | Seattle | 11/16/2008 | Seattle 32-13 | 94 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Receptions | Arizona | New York (AFC) | 9/28/2008 | New York (AFC) 31-28 | 58 |
| Most Receiving Yards | Arizona | New York (AFC) | 9/28/2008 | New York (AFC) 31-28 | 561 |
| Best Reception Yardage Avg | Minnesota | Atlanta | 12/21/2008 | Minnesota 24-15 | 23.9 |
| Longest Reception | Arizona | Seattle | 11/16/2008 | Seattle 32-13 | 94 |
| Kickoff Return Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Returns | Josh Wilson - Seattle | Tampa Bay | 10/19/2008 | Tampa Bay 44-21 | 8 |
| Best Return Yardage Avg | J.J. Arrington - Arizona | Seattle | 12/28/2008 | Arizona 31-28 | 94.0 |
| Longest Return | Leodis McKelvin - Buffalo | St. Louis | 9/28/2008 | Buffalo 38-24 | 102 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Returns | St. Louis | Atlanta | 12/28/2008 | Atlanta 55-21 | 9 |
| Best Return Yardage Avg | Chicago | Detroit | 10/5/2008 | Chicago 31-21 | 57.5 |
| Longest Return | Buffalo | St. Louis | 9/28/2008 | Buffalo 38-24 | 102 |
| Punt Return Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Returns | Will Blackmon - Green Bay | Carolina | 11/30/2008 | Carolina 14-10 | 7 |
| Best Return Yardage Avg | Harry Douglas - Atlanta | Philadelphia | 10/26/2008 | Atlanta 38-28 | 88.0 |
| Longest Return | Harry Douglas - Atlanta | Philadelphia | 10/26/2008 | Atlanta 38-28 | 88 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Returns | Green Bay | Carolina | 11/30/2008 | Carolina 14-10 | 7 |
| Best Return Yardage Avg | New Orleans | Tampa Bay | 9/7/2008 | New Orleans 29-27 | 79.0 |
| Longest Return | Atlanta | Philadelphia | 10/26/2008 | Atlanta 38-28 | 88 |
| Defense Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Tackles | Dhani Jones - Cincinnati | Pittsburgh | 11/20/2008 | Pittsburgh 21-3 | 19 |
| Sacks | DeMarcus Ware - Dallas | Baltimore | 12/20/2008 | Dallas 24-3 | 4 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Tackles | New York (AFC) | Arizona | 9/28/2008 | New York (AFC) 31-28 | 74 |
| Sacks | New York (AFC) | Buffalo | 12/14/2008 | New York (AFC) 27-22 | 7 |
| Interception Stats | |||||
| Player | |||||
| Stat | Player Name - Team | Opponent | Date | Score | Value |
| Most Interceptions | Ed Reed - Baltimore | Oakland | 10/26/2008 | Baltimore 39-20 | 4 |
| Best Interception Yardage Avg | Paris Lenon - Detroit | Chicago | 10/5/2008 | Chicago 31-21 | 88.0 |
| Longest Interception | Paris Lenon - Detroit | Chicago | 10/5/2008 | Chicago 31-21 | 88 |
| Team | |||||
| Stat | Team | Opponent | Date | Score | Value |
| Most Interceptions | Washington | Dallas | 11/16/2008 | Washington 38-21 | 6 |
| Best Interception Yardage Avg | Washington | Detroit | 10/26/2008 | Washington 34-10 | 79.0 |
| Longest Interception | Detroit | Chicago | 10/5/2008 | Chicago 31-21 | 88 |