| League Schedule | |
| Week 1 | |
| Matchup | Date/Score |
|---|---|
| Atlanta at Philadelphia | Atlanta wins 30-26 |
| Jacksonville at New York NFC | New York NFC wins 20-9 |
| Tampa Bay at New Orleans | New Orleans wins 38-20 |
| Cincinnati at Indianapolis | Indianapolis wins 20-19 |
| Buffalo at Baltimore | Baltimore wins 24-7 |
| Tennessee at Miami | Tennessee wins 27-24 |
| Houston at New England | New England wins 37-31 |
| San Francisco at Minnesota | San Francisco wins 21-10 |
| Kansas City at Los Angeles AFC | Los Angeles AFC wins 34-20 |
| Washington at Arizona | Washington wins 22-8 |
| Seattle at Denver | Seattle wins 33-24 |
| Dallas at Carolina | Carolina wins 20-15 |
| Chicago at Green Bay | Green Bay wins 23-17 |
| Pittsburgh at Cleveland | Cleveland wins 36-31 |
| New York AFC at Detroit | Detroit wins 30-27 |
| Los Angeles NFC at Oakland | Los Angeles NFC wins 44-7 |
| Week 2 | |
| Matchup | Date/Score |
| Baltimore at Cincinnati | Cincinnati wins 31-28 |
| Philadelphia at Tampa Bay | Philadelphia wins 28-21 |
| Los Angeles AFC at Buffalo | Los Angeles AFC wins 23-7 |
| Indianapolis at Washington | Indianapolis wins 20-13 |
| Minnesota at Green Bay | Minnesota wins 52-30 |
| Miami at New York AFC | New York AFC wins 27-24 |
| Carolina at Atlanta | Atlanta wins 31-28 |
| Houston at Tennessee | Tennessee wins 29-19 |
| Cleveland at New Orleans | New Orleans wins 30-24 |
| Detroit at San Francisco | San Francisco wins 31-30 |
| Arizona at Los Angeles NFC | Los Angeles NFC wins 21-20 |
| Oakland at Denver | Denver wins 34-27 |
| New England at Jacksonville | New England wins 19-16 |
| New York NFC at Dallas | Dallas wins 21-9 |
| Kansas City at Pittsburgh | Pittsburgh wins 35-20 |
| Seattle at Chicago | Chicago wins 19-16 |
| Week 3 | |
| Matchup | Date/Score |
| New York AFC at Cleveland | Manual |
| New York NFC at Houston | Manual |
| Denver at Baltimore | Manual |
| New Orleans at Atlanta | Manual |
| Tennessee at Jacksonville | Manual |
| Buffalo at Minnesota | Manual |
| San Francisco at Kansas City | Manual |
| Indianapolis at Philadelphia | Manual |
| Green Bay at Washington | Manual |
| Cincinnati at Carolina | Manual |
| Oakland at Miami | Manual |
| Los Angeles AFC at Los Angeles NFC | Los Angeles AFC wins 44-14 |
| Dallas at Seattle | Manual |
| Chicago at Arizona | Manual |
| New England at Detroit | Manual |
| Pittsburgh at Tampa Bay | Manual |
| Week 4 | |
| Matchup | Date/Score |
| Minnesota at Los Angeles NFC | 9/27/2018 |
| New York AFC at Jacksonville | 9/30/2018 |
| Buffalo at Green Bay | 9/30/2018 |
| Philadelphia at Tennessee | 9/30/2018 |
| Seattle at Arizona | 9/30/2018 |
| Cleveland at Oakland | 9/30/2018 |
| San Francisco at Los Angeles AFC | 9/30/2018 |
| New Orleans at New York NFC | 9/30/2018 |
| Baltimore at Pittsburgh | 9/30/2018 |
| Miami at New England | 9/30/2018 |
| Tampa Bay at Chicago | 9/30/2018 |
| Detroit at Dallas | 9/30/2018 |
| Cincinnati at Atlanta | 9/30/2018 |
| Houston at Indianapolis | 9/30/2018 |
| Kansas City at Denver | 10/1/2018 |
| Week 5 | |
| Matchup | Date/Score |
| Indianapolis at New England | 10/4/2018 |
| Jacksonville at Kansas City | 10/7/2018 |
| Green Bay at Detroit | 10/7/2018 |
| Tennessee at Buffalo | 10/7/2018 |
| Denver at New York AFC | 10/7/2018 |
| Baltimore at Cleveland | 10/7/2018 |
| Atlanta at Pittsburgh | 10/7/2018 |
| New York NFC at Carolina | 10/7/2018 |
| Dallas at Houston | 10/7/2018 |
| Los Angeles NFC at Seattle | 10/7/2018 |
| Arizona at San Francisco | 10/7/2018 |
| Minnesota at Philadelphia | 10/7/2018 |
| Oakland at Los Angeles AFC | 10/7/2018 |
| Miami at Cincinnati | 10/7/2018 |
| Washington at New Orleans | 10/8/2018 |
| Week 6 | |
| Matchup | Date/Score |
| Philadelphia at New York NFC | 10/11/2018 |
| Pittsburgh at Cincinnati | 10/14/2018 |
| Buffalo at Houston | 10/14/2018 |
| Los Angeles AFC at Cleveland | 10/14/2018 |
| Indianapolis at New York AFC | 10/14/2018 |
| Los Angeles NFC at Denver | 10/14/2018 |
| Jacksonville at Dallas | 10/14/2018 |
| Baltimore at Tennessee | 10/14/2018 |
| Kansas City at New England | 10/14/2018 |
| Tampa Bay at Atlanta | 10/14/2018 |
| Arizona at Minnesota | 10/14/2018 |
| Carolina at Washington | 10/14/2018 |
| Seattle at Oakland | 10/14/2018 |
| Chicago at Miami | 10/14/2018 |
| San Francisco at Green Bay | 10/15/2018 |
| Week 7 | |
| Matchup | Date/Score |
| Denver at Arizona | 10/18/2018 |
| Tennessee at Los Angeles AFC | 10/21/2018 |
| Carolina at Philadelphia | 10/21/2018 |
| New England at Chicago | 10/21/2018 |
| Detroit at Miami | 10/21/2018 |
| Houston at Jacksonville | 10/21/2018 |
| Minnesota at New York AFC | 10/21/2018 |
| Buffalo at Indianapolis | 10/21/2018 |
| New Orleans at Baltimore | 10/21/2018 |
| Cleveland at Tampa Bay | 10/21/2018 |
| Los Angeles NFC at San Francisco | 10/21/2018 |
| Cincinnati at Kansas City | 10/21/2018 |
| Dallas at Washington | 10/21/2018 |
| New York NFC at Atlanta | 10/22/2018 |
| Week 8 | |
| Matchup | Date/Score |
| Miami at Houston | 10/25/2018 |
| New Orleans at Minnesota | 10/28/2018 |
| Indianapolis at Oakland | 10/28/2018 |
| San Francisco at Arizona | 10/28/2018 |
| Green Bay at Los Angeles NFC | 10/28/2018 |
| Seattle at Detroit | 10/28/2018 |
| Cleveland at Pittsburgh | 10/28/2018 |
| Tampa Bay at Cincinnati | 10/28/2018 |
| Washington at New York NFC | 10/28/2018 |
| New York AFC at Chicago | 10/28/2018 |
| Baltimore at Carolina | 10/28/2018 |
| Denver at Kansas City | 10/28/2018 |
| Philadelphia at Jacksonville | 10/28/2018 |
| New England at Buffalo | 10/29/2018 |
| Week 9 | |
| Matchup | Date/Score |
| Oakland at San Francisco | 11/1/2018 |
| Los Angeles AFC at Seattle | 11/4/2018 |
| Chicago at Buffalo | 11/4/2018 |
| Los Angeles NFC at New Orleans | 11/4/2018 |
| Detroit at Minnesota | 11/4/2018 |
| New York AFC at Miami | 11/4/2018 |
| Pittsburgh at Baltimore | 11/4/2018 |
| Atlanta at Washington | 11/4/2018 |
| Tampa Bay at Carolina | 11/4/2018 |
| Green Bay at New England | 11/4/2018 |
| Houston at Denver | 11/4/2018 |
| Kansas City at Cleveland | 11/4/2018 |
| Tennessee at Dallas | 11/5/2018 |
| Week 10 | |
| Matchup | Date/Score |
| Carolina at Pittsburgh | 11/8/2018 |
| Los Angeles AFC at Oakland | 11/11/2018 |
| Miami at Green Bay | 11/11/2018 |
| Seattle at Los Angeles NFC | 11/11/2018 |
| Dallas at Philadelphia | 11/11/2018 |
| Atlanta at Cleveland | 11/11/2018 |
| New Orleans at Cincinnati | 11/11/2018 |
| Jacksonville at Indianapolis | 11/11/2018 |
| Washington at Tampa Bay | 11/11/2018 |
| Arizona at Kansas City | 11/11/2018 |
| Detroit at Chicago | 11/11/2018 |
| Buffalo at New York AFC | 11/11/2018 |
| New England at Tennessee | 11/11/2018 |
| New York NFC at San Francisco | 11/12/2018 |
| Week 11 | |
| Matchup | Date/Score |
| Green Bay at Seattle | 11/15/2018 |
| Oakland at Arizona | 11/18/2018 |
| Dallas at Atlanta | 11/18/2018 |
| Cincinnati at Baltimore | 11/18/2018 |
| Tampa Bay at New York NFC | 11/18/2018 |
| Pittsburgh at Jacksonville | 11/18/2018 |
| Carolina at Detroit | 11/18/2018 |
| Houston at Washington | 11/18/2018 |
| Tennessee at Indianapolis | 11/18/2018 |
| Philadelphia at New Orleans | 11/18/2018 |
| Minnesota at Chicago | 11/18/2018 |
| Denver at Los Angeles AFC | 11/18/2018 |
| Kansas City at Los Angeles NFC | 11/19/2018 |
| Week 12 | |
| Matchup | Date/Score |
| Atlanta at New Orleans | 11/22/2018 |
| Chicago at Detroit | 11/22/2018 |
| Washington at Dallas | 11/22/2018 |
| Green Bay at Minnesota | 11/25/2018 |
| Pittsburgh at Denver | 11/25/2018 |
| Miami at Indianapolis | 11/25/2018 |
| Arizona at Los Angeles AFC | 11/25/2018 |
| New York NFC at Philadelphia | 11/25/2018 |
| Jacksonville at Buffalo | 11/25/2018 |
| Cleveland at Cincinnati | 11/25/2018 |
| San Francisco at Tampa Bay | 11/25/2018 |
| Oakland at Baltimore | 11/25/2018 |
| Seattle at Carolina | 11/25/2018 |
| New England at New York AFC | 11/25/2018 |
| Tennessee at Houston | 11/26/2018 |
| Week 13 | |
| Matchup | Date/Score |
| New Orleans at Dallas | 11/29/2018 |
| Los Angeles NFC at Detroit | 12/2/2018 |
| Carolina at Tampa Bay | 12/2/2018 |
| Indianapolis at Jacksonville | 12/2/2018 |
| Chicago at New York NFC | 12/2/2018 |
| Arizona at Green Bay | 12/2/2018 |
| Denver at Cincinnati | 12/2/2018 |
| New York AFC at Tennessee | 12/2/2018 |
| Kansas City at Oakland | 12/2/2018 |
| Cleveland at Houston | 12/2/2018 |
| Baltimore at Atlanta | 12/2/2018 |
| Buffalo at Miami | 12/2/2018 |
| Los Angeles AFC at Pittsburgh | 12/2/2018 |
| Minnesota at New England | 12/2/2018 |
| San Francisco at Seattle | 12/2/2018 |
| Washington at Philadelphia | 12/3/2018 |
| Week 14 | |
| Matchup | Date/Score |
| Jacksonville at Tennessee | 12/6/2018 |
| Baltimore at Kansas City | 12/9/2018 |
| New York NFC at Washington | 12/9/2018 |
| Atlanta at Green Bay | 12/9/2018 |
| New England at Miami | 12/9/2018 |
| New York AFC at Buffalo | 12/9/2018 |
| Indianapolis at Houston | 12/9/2018 |
| Carolina at Cleveland | 12/9/2018 |
| New Orleans at Tampa Bay | 12/9/2018 |
| Cincinnati at Los Angeles AFC | 12/9/2018 |
| Denver at San Francisco | 12/9/2018 |
| Detroit at Arizona | 12/9/2018 |
| Philadelphia at Dallas | 12/9/2018 |
| Pittsburgh at Oakland | 12/9/2018 |
| Los Angeles NFC at Chicago | 12/9/2018 |
| Minnesota at Seattle | 12/10/2018 |
| Week 15 | |
| Matchup | Date/Score |
| Los Angeles AFC at Kansas City | 12/13/2018 |
| Houston at New York AFC | 12/15/2018 |
| Cleveland at Denver | 12/15/2018 |
| Miami at Minnesota | 12/16/2018 |
| Dallas at Indianapolis | 12/16/2018 |
| Philadelphia at Los Angeles NFC | 12/16/2018 |
| New England at Pittsburgh | 12/16/2018 |
| Seattle at San Francisco | 12/16/2018 |
| Oakland at Cincinnati | 12/16/2018 |
| Arizona at Atlanta | 12/16/2018 |
| Tampa Bay at Baltimore | 12/16/2018 |
| Green Bay at Chicago | 12/16/2018 |
| Tennessee at New York NFC | 12/16/2018 |
| Detroit at Buffalo | 12/16/2018 |
| Washington at Jacksonville | 12/16/2018 |
| New Orleans at Carolina | 12/17/2018 |
| Week 16 | |
| Matchup | Date/Score |
| Baltimore at Los Angeles AFC | 12/22/2018 |
| Washington at Tennessee | 12/22/2018 |
| Green Bay at New York AFC | 12/23/2018 |
| Los Angeles NFC at Arizona | 12/23/2018 |
| Chicago at San Francisco | 12/23/2018 |
| Pittsburgh at New Orleans | 12/23/2018 |
| Kansas City at Seattle | 12/23/2018 |
| Tampa Bay at Dallas | 12/23/2018 |
| Buffalo at New England | 12/23/2018 |
| New York NFC at Indianapolis | 12/23/2018 |
| Minnesota at Detroit | 12/23/2018 |
| Jacksonville at Miami | 12/23/2018 |
| Atlanta at Carolina | 12/23/2018 |
| Cincinnati at Cleveland | 12/23/2018 |
| Houston at Philadelphia | 12/23/2018 |
| Denver at Oakland | 12/24/2018 |
| Week 17 | |
| Matchup | Date/Score |
| Dallas at New York NFC | 12/30/2018 |
| Miami at Buffalo | 12/30/2018 |
| Carolina at New Orleans | 12/30/2018 |
| Atlanta at Tampa Bay | 12/30/2018 |
| Detroit at Green Bay | 12/30/2018 |
| Indianapolis at Tennessee | 12/30/2018 |
| Cincinnati at Pittsburgh | 12/30/2018 |
| Arizona at Seattle | 12/30/2018 |
| Cleveland at Baltimore | 12/30/2018 |
| Philadelphia at Washington | 12/30/2018 |
| Los Angeles AFC at Denver | 12/30/2018 |
| New York AFC at New England | 12/30/2018 |
| Oakland at Kansas City | 12/30/2018 |
| San Francisco at Los Angeles NFC | 12/30/2018 |
| Jacksonville at Houston | 12/30/2018 |
| Chicago at Minnesota | 12/30/2018 |