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| Tuesday, November 2nd, 2021 |
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| GM Butch Ellis retires. |
| Wednesday, July 7th, 2021 |
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| Released SP Shosuke Watanabe. |
| Wednesday, June 23rd, 2021 |
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| Released 1B Julián Martínez. |
| Tuesday, June 22nd, 2021 |
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| Released CL Juan Martínez. |
| Thursday, June 17th, 2021 |
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| Released SP Ronaldo Pérez. |
| Wednesday, June 16th, 2021 |
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| Released SP Mike MacInroy. |
| Released RF Gregg Green. |
| Released SP Elliott Rogers. |
| Wednesday, June 9th, 2021 |
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| Signed scouting director Don Potter. |
| Monday, June 7th, 2021 |
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| Released 3B Cornell Frank. |
| Released 2B Ramón Vela. |
| Released SP Stephen Bowen. |
| Released SP James Thompson. |
| Released MR Dermott Shill. |
| Released SP Jon Shipway. |
| Released LF Alberto Ruíz. |
| SP Joe Linn joins the team. |
| SP Steve Hill joins the team. |
| SP Alejandro Román joins the team. |
| MR José Vallejo joins the team. |
| MR Jorge González joins the team. |
| MR Stan Hines joins the team. |
| MR Shawn Thomas joins the team. |
| C Rickey Hall joins the team. |
| C José Hernández joins the team. |
| C Edgar Hudson joins the team. |
| 2B Chang-yong Yu joins the team. |
| 3B Matthew Arnold joins the team. |
| SS Teófilo Krusse joins the team. |
| LF Jeff Tomlinson joins the team. |
| CF Quinton Slate joins the team. |
| 1B Min Khu joins the team. |
| 3B Wes Jardine joins the team. |
| 1B Sergio Ledesma joins the team. |
| Wednesday, June 2nd, 2021 |
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| Signed General Manager Butch Ellis to a 1-year contract extension. |
| Signed Pitching Coach Edwin Spence to a 1-year contract extension. |
| Scouting Director Kichisaburo Watanabe leaves the team, his contract was not renewed. |
| CF Connor Smith joins the team. |
| SS Andrej de Goedere joins the team. |
| C Ramón Torrez joins the team. |
