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| Monday, November 8th, 2021 |
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| Signed scouting director Jack Howlands. |
| Tuesday, November 2nd, 2021 |
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| SC Pedro Pérez retires. |
| Wednesday, June 16th, 2021 |
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| Released SP Joe Good. |
| Monday, June 7th, 2021 |
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| SP Juan Rivera joins the team. |
| SP Jason Williams joins the team. |
| SP Miguel Ruíz joins the team. |
| MR Laurent Berthelot joins the team. |
| MR Fred Harris joins the team. |
| MR Donald Chambers joins the team. |
| MR Rudy Racine joins the team. |
| MR Edgardo Hernández joins the team. |
| MR Bill Lacy joins the team. |
| C Iván Lavio joins the team. |
| C Bob Franklin joins the team. |
| 2B James Murray joins the team. |
| LF Andrew Thompson joins the team. |
| RF Luis Núñez joins the team. |
| SS Geoff Gibbs joins the team. |
| SS Frank Bay joins the team. |
| RF Lorenzo Garza joins the team. |
| Wednesday, May 19th, 2021 |
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| Signed general manager Tadao Suzuki. |
| Sunday, May 16th, 2021 |
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| Signed manager Michael Simpson. |
| Tuesday, May 11th, 2021 |
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| Signed hitting coach John Leiker. |
| Wednesday, May 5th, 2021 |
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| Released CL Troy Dyer. |
| Released C Manuel Meléndez. |
| Released SS John Walker. |
| Released MR Leonardo Alba. |
| Released SP Aubrey Lester. |
| Released 2B Mario Nava. |
| Released LF Vicente Torres. |
| Released CF Héctor Rivas. |
| Released MR Jonah King. |
| Fired general manager Romain De Sousa. |
| Fired manager Isoruko Kamida. |
| Signed Pitching Coach Marcel Devaux to a 1-year contract extension. |
| Hitting Coach Glen Bailey leaves the team, his contract was not renewed. |
| SS Jesús Valdés joins the team. |
| SP Lorenzo Muñóz joins the team. |
| SP Timothy Hill joins the team. |
| SP Ángel Morales joins the team. |
| MR Chris Benson joins the team. |
| C Ramón Giraldes joins the team. |
