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| Sunday, July 4th, 2021 |
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| Released SS Bernardo Rodríguez. |
| Wednesday, June 23rd, 2021 |
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| Released SP Robert Cook. |
| Wednesday, June 16th, 2021 |
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| Released SP Orlando Días. |
| Monday, June 7th, 2021 |
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| Released SP Austin Price. |
| Released SP Archie McCarty. |
| SP Javier García joins the team. |
| SP Felipe Rodríguez joins the team. |
| SP Álex López joins the team. |
| MR Odalis Franco joins the team. |
| MR Fred Tobias joins the team. |
| MR Jacob Conner joins the team. |
| MR Rich Harrell joins the team. |
| MR Carl Marshall joins the team. |
| C Malcolm Jenkins joins the team. |
| C Brice Haddad joins the team. |
| C Matthew Robinson joins the team. |
| LF Jack Lucas joins the team. |
| 3B Dan Young joins the team. |
| 2B Bob Washington joins the team. |
| Saturday, May 15th, 2021 |
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| Signed team doctor Glenn Otto. |
| Wednesday, May 5th, 2021 |
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| Released MR John Trainor. |
| Released 1B António Lugo. |
| Released CL Rafael Gutiérrez. |
| Released LF Louis McCann. |
| Released SS Jorge Rodríguez. |
| Released C Vugar Oguz. |
| Released SP Arturo Salinas. |
| Signed General Manager Brian Butler to a 1-year contract extension. |
| Signed Manager Nakazo Kobayashi to a 3-year contract extension. |
| Team Trainer Clint Harris leaves the team, his contract was not renewed. |
| SP Jacques Sanchez joins the team. |
| 3B José Mellgoza joins the team. |
| MR Lúcio Ledesma joins the team. |
| MR Austin Price joins the team. |
| C Albert Rodríguez joins the team. |
