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| Tuesday, November 16th, 2021 |
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| Signed team doctor Alex Haines. |
| Tuesday, November 2nd, 2021 |
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| DO Ienobu Shinoda retires. |
| Monday, June 7th, 2021 |
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| Signed bench coach Glen Bailey. |
| Released 1B Jesús Valenzuela. |
| SP Juan Marino joins the team. |
| SP Alfredo Crespo joins the team. |
| SP Vern Montgomery joins the team. |
| SP Scott Moore joins the team. |
| MR Paul Hensley joins the team. |
| MR Rod Foley joins the team. |
| MR Steven Sweeney joins the team. |
| MR Pedro Álvarez joins the team. |
| C Arturo Casanes joins the team. |
| C Juanito Díaz joins the team. |
| 1B José Martínez joins the team. |
| 2B Roberto Chávez joins the team. |
| 3B Tommy Baker joins the team. |
| SS Manuel Garza joins the team. |
| 2B Félix Cháves joins the team. |
| Saturday, May 22nd, 2021 |
|---|
| Signed team doctor Ienobu Shinoda. |
| Wednesday, May 5th, 2021 |
|---|
| Released RF Francisco Garza. |
| Released LF Erik Warren. |
| Released C Alfonso Flores. |
| Released MR Roger Bryant. |
| Released C Reynaldo Villa. |
| Bench Coach Jake White leaves the team, his contract was not renewed. |
| Signed Pitching Coach Keith Shannon to a 1-year contract extension. |
| Signed Hitting Coach Ragnvard Jullander to a 2-year contract extension. |
| Team Trainer Roy Allen leaves the team, his contract was not renewed. |
| CF Scott Gibbons joins the team. |
| LF Ian King joins the team. |
| SP Steve Pérez joins the team. |
| SP Jorge Villa joins the team. |
| C Todd Davis joins the team. |
| C Michael Slaughter joins the team. |
