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| Monday, June 7th, 2021 |
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| SP Tony Maloney joins the team. |
| SP Greg Carter joins the team. |
| SP Raúl Flores joins the team. |
| SP Rob Johnson joins the team. |
| MR Peter Townsley joins the team. |
| MR Vicente Valenzuela joins the team. |
| MR Octávio Mendoza joins the team. |
| C Roger Slater joins the team. |
| 2B René Legendre joins the team. |
| 3B Jorge Salinas joins the team. |
| LF Davy Foote joins the team. |
| CF Fernando Vega joins the team. |
| SS Jorge Martínez joins the team. |
| 3B Jeff Berry joins the team. |
| Saturday, May 15th, 2021 |
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| Signed team doctor Miguel Días. |
| Wednesday, May 5th, 2021 |
|---|
| Released SP Lucas Iddon. |
| Released MR Dave Thompson. |
| Released SP George Young. |
| Released RF Alberto Lepe. |
| Released C Steven Gauthier. |
| Released LF Pedro Deleón. |
| Released CF Duane Hensley. |
| Released LF Arturo Martínez. |
| Released MR Brian Barnes. |
| Signed Pitching Coach David Lamb to a 1-year contract extension. |
| Signed Hitting Coach Rick Osmond to a 1-year contract extension. |
| Team Trainer Katsumi Narita leaves the team, his contract was not renewed. |
| SP Dexter Nichols joins the team. |
| SS Rob Butler joins the team. |
| SP José Córdova joins the team. |
| SP Lúcio Pérez joins the team. |
| RF Marcos Rivera joins the team. |
| RF Mike Hayes joins the team. |
| SS Fraser García joins the team. |
