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| Tuesday, November 2nd, 2021 |
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| GM Ángel Ruíz retires. |
| Thursday, September 23rd, 2021 |
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| Signed general manager Ángel Ruíz. |
| Monday, June 7th, 2021 |
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| SP John Payne joins the team. |
| SP George McGinnis joins the team. |
| SP Jeff Nelson joins the team. |
| SP Greg Hall joins the team. |
| MR Sam Williams joins the team. |
| MR José Torres joins the team. |
| MR José González joins the team. |
| MR Harry Myers joins the team. |
| MR Ramón Robles joins the team. |
| MR Serge Dupré joins the team. |
| C Jim Tiller joins the team. |
| C Haden Inches joins the team. |
| 1B Bruce Jackson joins the team. |
| 2B Eric Swinney joins the team. |
| 3B Bill Robinson joins the team. |
| CF Ralph Willis joins the team. |
| Friday, May 28th, 2021 |
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| Signed manager Jeffrey Woodruff. |
| Sunday, May 23rd, 2021 |
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| Signed team doctor Katsumi Narita. |
| Wednesday, May 5th, 2021 |
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| Released C John Broomhall. |
| Released C Desi Whitfield. |
| Released SP Pat MacDougall. |
| Released MR Randy Foster. |
| Released CL Alberto Durango. |
| Released SP Robert Thompson. |
| Released MR Matt Cooper. |
| MA Ed Thompson retires. |
| Fired general manager Ramón Varela. |
| Signed Pitching Coach Eric Young to a 3-year contract extension. |
| Signed Hitting Coach Dave Frederick to a 3-year contract extension. |
| Team Trainer Robert Smith leaves the team, his contract was not renewed. |
| SS Martín Prado joins the team. |
| SS Peter Stephens joins the team. |
| MR José Lara joins the team. |
| MR António Salgado joins the team. |
| C Denis Myers joins the team. |
| C Martín Navedo joins the team. |
