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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
| O'Day, Craig | LF | South Carolina Bombers | 35 | 02/07/1981 | Staten Island | USA | Left | Left | 6' 0" | 209 lbs | $1,800,000 |
| O'Higgins, Reese | 2B | Ann Arbor Barn Owls | 26 | 06/29/1990 | Rialto | USA | Right | Right | 5' 8" | 175 lbs | $500,000 |
| O'Keggan, Brian | MR | Free Agent | 31 | 08/01/1985 | Eaton Rapids | USA | Right | Right | 5' 7" | 198 lbs | - |
| O'Neal, Joe | CF | Nottinghamshire Outlaws | 26 | 05/31/1990 | Upton | USA | Left | Left | 6' 0" | 183 lbs | $7,500,000 |
| O'Neil, Clayton | CL | San Francisco Earthquakes | 23 | 08/11/1993 | Iselin | USA | Right | Right | 6' 0" | 255 lbs | $500,000 |
| O'Quinn, Roy | RF | South Carolina Bombers | 23 | 04/06/1993 | Philadelphia | USA | Left | Left | 5' 9" | 180 lbs | $1,250,000 |
| O'Reilly, Gene | C | Washington Capitalists | 30 | 02/26/1986 | West Des Moines | USA | Left | Right | 6' 4" | 225 lbs | $1,170,000 |
| Oditón, León | C | South Carolina Bombers | 29 | 05/29/1987 | Burlington | USA | Switch | Right | 6' 0" | 193 lbs | $4,700,000 |
| Ogura, Jun'ichi | SS | South Bend Shamrocks | 24 | 02/28/1992 | Motegi | JPN | Right | Right | 6' 0" | 180 lbs | $500,000 |
| Olsen, Jeff | SP | Las Vegas Jokers | 27 | 09/11/1989 | Barrington | USA | Left | Left | 6' 2" | 163 lbs | $800,000 |
| Ortega, Ramiro | MR | Carolina Crush | 26 | 05/26/1990 | Netcong | USA | Right | Right | 6' 0" | 175 lbs | $1,200,000 |
| Ortíz, Iván | RF | Free Agent | 30 | 01/23/1986 | Maracaibo | VEN | Right | Right | 5' 11" | 192 lbs | - |
| Ortíz, José | 2B | Las Vegas Jokers | 29 | 08/24/1987 | Delicias | MEX | Right | Right | 6' 3" | 162 lbs | $900,000 |
| Ortíz, Juan Carlos | LF | South Bend Shamrocks | 20 | 02/17/1996 | Valencia | VEN | Left | Right | 6' 0" | 170 lbs | $500,000 |
| Ortíz, Miguel Angel | 1B | San Diego Hops | 34 | 03/22/1982 | Santo Domingo | DOM | Right | Right | 6' 8" | 206 lbs | $19,000,000 |
| Ortíz, Roberto | 2B | Free Agent | 25 | 09/16/1991 | Keyport | USA | Left | Right | 5' 8" | 187 lbs | - |
| Osborn, Bob | CF | So Cal Republic | 27 | 01/23/1989 | Quincy | USA | Right | Right | 6' 3" | 178 lbs | $2,500,000 |
| Osborne, Robert | SP | Maple Marauders | 25 | 05/25/1991 | Kansas City | USA | Left | Left | 6' 4" | 212 lbs | $500,000 |
| Otero, Eduardo | RF | Eureka Hornets | 25 | 08/08/1991 | Mayagüez | PUR | Left | Left | 6' 3" | 220 lbs | $500,000 |
| Owens, Ryan | SP | Mile High Mustangs | 27 | 04/07/1989 | Miami Beach | USA | Left | Right | 6' 0" | 205 lbs | $500,000 |
| Owens, Tom | SP | Dallas Texans | 26 | 05/24/1990 | Billerica | USA | Right | Right | 6' 0" | 212 lbs | $18,950,000 |
| Owens, Tom | SP | Jersey Jesters | 23 | 08/19/1993 | Brooklyn | USA | Right | Right | 6' 6" | 245 lbs | $1,785,000 |
