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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
| O'Connor, Charles | MR | Las Vegas Jokers | 37 | 11/24/1976 | Algonquin | USA | Right | Right | 5' 11" | 205 lbs | $7,850,000 |
| O'Day, Craig | LF | Montgomery Mountain Cats | 32 | 02/07/1981 | Staten Island | USA | Left | Left | 6' 0" | 211 lbs | $12,500,000 |
| O'Donnell, Steve | SS | Georgia Ghost Busters | 34 | 08/15/1979 | Carrollton | USA | Right | Right | 5' 10" | 202 lbs | $10,500,000 |
| O'Keggan, Brian | SP | San Francisco Earthquakes | 28 | 08/01/1985 | Eaton Rapids | USA | Right | Right | 5' 7" | 190 lbs | $787,500 |
| O'Macken, Jeff | SP | Free Agent | 31 | 02/12/1982 | Montecito | USA | Right | Right | 6' 0" | 218 lbs | - |
| O'Neil, Robert | LF | South Carolina Bombers | 27 | 01/25/1986 | Rock Island | USA | Left | Left | 6' 2" | 230 lbs | $500,000 |
| O'Neill, Jayson | C | South Carolina Bombers | 26 | 04/04/1987 | Spanish Springs | USA | Right | Right | 6' 2" | 195 lbs | $1,000,000 |
| O'Reilly, Foster | C | New York Mafia | 25 | 04/21/1988 | Millersville | USA | Switch | Right | 6' 0" | 205 lbs | $500,000 |
| O'Reilly, Gene | C | Montreal Bandits | 27 | 02/26/1986 | West Des Moines | USA | Left | Right | 6' 4" | 221 lbs | $750,000 |
| Oditón, León | C | Seattle Sasquatch | 26 | 05/29/1987 | Burlington | USA | Switch | Right | 6' 0" | 197 lbs | $510,000 |
| Oike, Shuncho | 3B | San Diego Hops | 32 | 02/27/1981 | Funabashi | JPN | Right | Right | 6' 2" | 216 lbs | - |
| Okada, Tsumemasa | MR | Minnesota Berserkers | 35 | 02/04/1978 | Ube | JPN | Switch | Left | 6' 0" | 212 lbs | $3,500,000 |
| Olsen, Jeff | SP | Las Vegas Jokers | 24 | 09/11/1989 | Barrington | USA | Left | Left | 6' 2" | 165 lbs | $500,000 |
| Olsen, Marshall | CL | Kansas City Tornadoes | 37 | 05/12/1976 | Brooklyn | USA | Left | Left | 6' 1" | 206 lbs | $3,000,000 |
| Olson, Dave | LF | New York Mafia | 28 | 07/25/1985 | New York | USA | Right | Right | 6' 0" | 210 lbs | $5,000,000 |
| Ortega, Ramiro | MR | Carolina Crush | 23 | 05/26/1990 | Netcong | USA | Right | Right | 6' 0" | 175 lbs | $510,000 |
| Ortíz, Iván | LF | Jacksonville Jacks | 27 | 01/23/1986 | Maracaibo | VEN | Right | Right | 5' 11" | 186 lbs | $510,000 |
| Ortíz, José | 2B | Las Vegas Jokers | 26 | 08/24/1987 | Delicias | MEX | Right | Right | 6' 3" | 160 lbs | $510,000 |
| Ortíz, Miguel Angel | 1B | San Diego Hops | 31 | 03/22/1982 | Santo Domingo | DOM | Right | Right | 6' 8" | 210 lbs | $17,000,000 |
| Ortíz, Santiago | SP | Free Agent | 26 | 04/20/1987 | Belle Glade | USA | Left | Right | 6' 4" | 230 lbs | - |
| Orton, Conrad | CL | Eureka Hornets | 18 | 03/25/1995 | Ottawa | CAN | Right | Right | 6' 0" | 210 lbs | - |
| Osborn, Bob | CF | So Cal Republic | 24 | 01/23/1989 | Quincy | USA | Right | Right | 6' 3" | 180 lbs | $1,200,000 |
| Owens, Ryan | SP | Las Vegas Jokers | 24 | 04/07/1989 | Miami Beach | USA | Left | Right | 6' 0" | 205 lbs | $500,000 |
| Owens, Tom | MR | Dallas Texans | 23 | 05/24/1990 | Billerica | USA | Right | Right | 6' 0" | 210 lbs | $510,000 |
