| | | Thursday, October 4th, 2012 | | Signed LF Juan Ramírez to a 3-year contract extension worth a total of $27,000,000. |
| Monday, September 17th, 2012 | | Placed CF Ryan Taylor on the 60-day disabled list. | | Placed SS Pedro Vega on the active roster. | | Placed SS Walt Dobson on the active roster. | | Activated SS Walt Dobson from the disabled list. |
| Tuesday, September 11th, 2012 | | Signed C Victor Welsh to a 3-year contract extension worth a total of $11,850,000. | | Signed MR King Smith to a 3-year contract extension worth a total of $2,400,000. | | Signed 3B Eric Williams to a 2-year contract extension worth a total of $2,900,000. | | Signed MR Robert Hedrick to a 2-year contract extension worth a total of $1,940,000. |
| Sunday, June 3rd, 2012 | | Signed CL Johnny Tiller to a 4-year contract extension worth a total of $28,000,000. | | Placed CL Chris Neal on the 60-day disabled list. |
| Saturday, June 2nd, 2012 | | Placed SS Pedro Vega on the 60-day disabled list. |
| Monday, April 23rd, 2012 | | Placed CF Ryan Taylor on the 60-day disabled list. |
| Saturday, March 17th, 2012 | | Placed CF Frank Johnston on the 14-day disabled list, retroactive to 03/08/2012. | | Placed CF Ryan Taylor on the 14-day disabled list, retroactive to 03/11/2012. | | Purchased the contract of LF Alfredo Martínez from Triple A Birmingham. |
| Sunday, March 4th, 2012 | | Signed manager Glenn Rowe to a 5-year, $740,000 per year contract. |
| Friday, January 20th, 2012 | | Signed team doctor Justin Neal to a 4-year, $730,000 per year contract. |
| Tuesday, January 17th, 2012 | | Signed bench coach Willy Delhaye to a 5-year, $860,000 per year contract. |
| Tuesday, January 3rd, 2012 | | Signed hitting coach Héctor Ledesma to a 5-year, $530,000 per year contract. |
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