| | | Thursday, September 27th, 2012 | | MR Daniel Brown was designated for assignment and placed on waivers. |
| Monday, September 24th, 2012 | | SP Ozzy Prince was designated for assignment and placed on waivers. | | MR Kevin Lewis was designated for assignment and placed on waivers. | | 2B Ken Peters was designated for assignment and placed on waivers. |
| Monday, June 25th, 2012 | | Purchased the contract of CF Joe Stone from Triple A Acapulco. |
| Monday, May 14th, 2012 | | Placed LF Dave Olson on the 14-day disabled list, retroactive to 05/12/2012. | | Purchased the contract of CF Joe Stone from Triple A Acapulco. |
| Friday, March 16th, 2012 | | Signed SP Arthur Gardner to a 3-year contract extension worth a total of $21,000,000. |
| Wednesday, March 7th, 2012 | | Signed MR Ronald Hart to a 4-year contract extension worth a total of $19,000,000. |
| Tuesday, February 28th, 2012 | | Signed C Ashton Finley to a 6-year contract extension worth a total of $84,200,000. |
| Friday, January 6th, 2012 | | Signed pitching coach Ryan Clark to a 5-year, $1,750,000 per year contract. |
| Thursday, January 5th, 2012 | | Signed bench coach Carlos Sosa to a 5-year, $740,000 per year contract. | | Signed hitting coach Masaaki Kurihara to a 5-year, $1,150,000 per year contract. |
| Tuesday, January 3rd, 2012 | | Signed team doctor Michael Davis to a 5-year, $530,000 per year contract. | | Signed manager Jaime Cantú to a 5-year, $2,600,000 per year contract. |
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