| | | Saturday, December 15th, 2012 | | Placed CF Dave Carlisle on the active roster. | | Activated CF Dave Carlisle from the 60-day disabled list. |
| Saturday, December 8th, 2012 | | Signed free agent SP Pepe López to a 4-year contract worth a total of $16,000,000. |
| Thursday, December 6th, 2012 | | Signed free agent MR Bob Hardin to a 2-year contract worth a total of $1,880,000. |
| Tuesday, November 27th, 2012 | | Signed SP Charles Luce to a 4-year contract extension worth a total of $28,800,000. |
| Friday, November 23rd, 2012 | | Signed 1B Dan Smith to a 5-year contract extension worth a total of $57,360,000. |
| Wednesday, November 21st, 2012 | | SP Stephen Lawrence received a 1-year contract through automatic renewal worth a total of $510,000. | | SP Edward Griffith received a 1-year contract through automatic renewal worth a total of $500,000. | | C John Robertson received a 1-year contract through automatic renewal worth a total of $510,000. | | SS Bret Garrison received a 1-year contract through automatic renewal worth a total of $510,000. | | 2B Domingo Blanchard received a 1-year contract through automatic renewal worth a total of $500,000. | | MR Juan Velázquez becomes a free-agent. | | RF Derek Tyler received a 1-year contract through automatic renewal worth a total of $500,000. |
| Sunday, November 18th, 2012 | | 1B Dan Smith received a 1-year contract through arbitration worth a total of $8,125,000. | | MR Derek Sears received a 1-year contract through arbitration worth a total of $750,000. | | CL Gregory Erwin received a 1-year contract through arbitration worth a total of $5,953,750. | | MR Willie Patterson received a 1-year contract through arbitration worth a total of $2,640,000. | | LF Dennis Crawford received a 1-year contract through arbitration worth a total of $1,800,000. | | CF Mark Bennett received a 1-year contract through arbitration worth a total of $750,000. | | MR Bob Hardin becomes a free-agent. | | RF Miguel Torres received a 1-year contract through arbitration worth a total of $5,280,000. |
| Wednesday, November 7th, 2012 | | Signed 2B Chris Cook to a 3-year contract extension worth a total of $3,150,000. |
| Friday, November 2nd, 2012 | | Signed hitting coach Jack O'Callahan to a 5-year, $420,000 per year contract. |
| Wednesday, October 31st, 2012 | | Placed RF Max Abrams on the active roster. | | Activated RF Max Abrams from the disabled list. |
| Sunday, October 28th, 2012 | | RF Bill Lee retires. | | Hitting Coach Ed Taylor leaves the team, his contract was not renewed. |
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